ABSTRACT
Background: Endotracheal intubation is routinely practiced in general anaesthesia, with potential hemodynamic effects on patients
Objective: The objective of this study was to compare the efficacy of single bolus intravenous lignocaine with magnesium sulphate to attenuate the haemodynamic response of laryngoscopy and intubation
Material and Methods: A total of 178 patients were included, randomly dividing them in two groups, 89 in each group. Group A, received intravenous 1% lignocaine 1mg/kg and group-B intravenous magnesium sulphate 10mg/kg. The data on heart rate, mean arterial pressure was compared among both groups and with baseline values, for the purpose of comparing efficacy. The data was entered and analyzed in SPSS version 14. Students t test was applied to compare means. AP-value of less than 5% was taken as significant. Study design: Double Blind Randomized Clinical Trial. Place and duration of study: Departments of Anesthesiology of CMH Multan, from 1[st] September, 2010 to 1[st] March 2011
Results: There was statistically significant difference between the two groups in terms of efficacy i.e. reduction of press or response to laryngoscopy and intubation. 20% reductions in Mean Arterial Pressure [MAP] from baseline values were observed in 54% of the patients in Group A and 36.69% in group B. Similarly, 25% reduction in heart rate [HR] from baseline values were observed in 11% of the patients in Group A and 6.23% in Group B. Incidence of > 20% increase in MAP was 4.2% in Group A versus 20.6% in group B and > 25% increase in HR 12.35% in group A versus 25.6% in Group B. Incidence of >20% increase in MAP was 4.2% in group A versus 20.6% in Group B and > 25% increase in HR 12.35% in group A versus 25.6% in Group B
Conclusion: There is statistically significant difference between two groups that is, lignocaine was more effective and efficacious than magnesium sulphate by preventing the increase in MAP and HR after laryngoscopy and intubation
ABSTRACT
Background: Endotracheal intubation is routinely practiced in general anaesthesia, with potential hemodynamic effects on patients
Objective: The objective of this study was to compare the efficacy of single bolus intravenous lignocaine with magnesium sulphate to attenuate the haemodynamic response of laryngoscopy and intubation
Material and Methods: Atotal of 178 patients were included, randomly dividing them in two groups, 89 in each group. Group A, received intravenous 1% lignocaine Img/kg and group-B intravenous magnesium sulphate lOmg/kg. The data on heart rate, mean arterial pressure was compared among both groups and with baseline values, for the purpose of comparing efficacy. The data was entered and analyzed in SPSS version 14. Students t test was applied to compare means. A P value of less than 5% was taken as significant. Study design: Double Blind Randomized Clinical Trial. Place and duration of study: Departments of Anesthesiology of CMH Multan, from 1[st] September, 2010 to 1[st] March 2011
Results: There was statistically significant difference between the two groups in terms of efficacy i.e reduction of pressor response to laryngoscopy and intubation. 20% reductions in Mean Arterial Pressure [MAP] from baseline values were observed in 54% of the patients in Group A and 36.69% in group B. Similarly, 25% reduction in heart rate [HR] from baseline values were observed in 11 % of the patients in Group A and 6.23% in Group B. Incidence of > 20% increase in MAP was 4.2 % in Group A versus 20.6 % in group B and > 25% increase in HR 12.35% in group A versus 25.6 % in Group B. Incidence of >20% increase in MAP was 4.2% in group A versus 20.6% in Group B and > 25 % increase in HR 12.35% in group A versus 25.6% in Group B
Conclusion: There is statistically significant difference between two groups that is, lignocaine was more effective and efficacious than magnesium sulphate by preventing the increase in MAP and HR after laryngoscopy and intubation